Our news research article is out in Molecular Metabolism

We are delighted to share that our paper “Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis” is in press now in Molecular Metabolism! Liver fibrosis is largely acknowledged to be reversible but little is known about the mechanisms controlling ECM remodeling during resolution. ➡ Our work shades new light on how macrophages contribute to liver fibrosis resolution. We describe how lysosomal protease CtsD contributes to the macrophage degradomic shift, which comprises secretomic, phenotypical and functional changes, required by macrophages to proteolytically process the ECM during liver fibrosis resolution. If you want to know more about CtsD being the new cool kid 😎 in the lysosomal block please check out our paper in Molecular Metabolism in the following link: https://www.sciencedirect.com/science/article/pii/S2212877824001200#abs0020 Congratulations the first authors Paloma Ruiz Blázquez, María Fernández Fernández and Valeria Pistorio 👩‍🔬 and the rest of the TRFCLab (Júlia Cacho, Alejandro del Castillo Cruz) for their hard-work, passion and dedication. This work has been possible thanks to our funders: Ministry of Science and Innovation of Spain, CSIC, PFIZER INC., Ministerio de Educación, España.